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Senior Research Scientist - Genomic Analysis - Oncology

AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide.

At AstraZeneca we believe in the potential of our people and you’ll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us.

Are you enthusiastic to investigate genomic and transcriptomic based approaches to understand preclinical oncology assay systems?  Are you keen to continue delivering at the bench and enhancing the oncology portfolio of a global biopharmaceutical company?  At AstraZeneca, we have an exciting opportunity for a Senior Research Scientist in Oncology Bioscience.

AstraZeneca’s vision in Oncology is to help patients by redefining the cancer-treatment paradigm, with the aim of bringing six new cancer medicines to patients between 2013 and 2020. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and haematological cancers. As well as other tumour types, these are being targeted through three key platforms - immunotherapy, the genetic drivers of cancer and resistance and DNA damage response, underpinned by personalised healthcare and biomarker technologies.  AstraZeneca have a clear commitment to Oncology which is now being reinforced with investment in a new, state-of-the-art Global R&D centre in Cambridge.  With unrivalled facilities and uniquely talented scientists, this will become the focal point for oncology within AstraZeneca and key to furthering our reputation as global leaders in the field.

Joining us in Cambridge, you’ll be able to push new boundaries in oncology research.  We will encourage you to support the development of novel therapeutics and biomarkers, identify new targets and publish your work.  You will be involved in all stages of the drug discovery and development process – and as your experience grows, so will your role and career prospects.

Main duties and responsibilities:

You will be part of the genomics team, supporting genomic requests from our large preclinical oncology portfolio. You’ll be supporting a broad variety of oncology projects in the lab by performing medium to high throughput PCR from in vitro and ex vivo samples. You will be responsible for independently analysing and troubleshooting the data and reporting the outcomes back to the project team.  You will also have a key role in next-generation sequencing from sample and library preparations to data interpretation.  You’ll work collaboratively with project teams, bioinformaticians and scientists from across AstraZeneca.  You will also get opportunities to introduce and develop novel genomic methodologies.

Essential requirements:

  • A PhD in biology or related field or equivalent industry experience
  • Enthusiasm to continuing delivering from the bench
  • Hands-on experience of nucleic acid based biomarker assay (RNA/DNA) and expertise in molecular technologies such as PCR and next-generation sequencing.
  • Experience with Illumina, or other, next-generation sequencing systems and library preparation.
  • Experience analysing and interpreting large scientific data sets including next-generation sequencing datasets. 
  • Ability to prioritise own workload and to work as part of a team
  • Attention to detail
  • Ability to collaborate with colleagues in a multidisciplinary setting
  • Good computer skills in order to learn high through put PCR analysis methods.

Desired requirements:

  • Industry experience
  • Experience working on oncology projects
  • Experience in R programming
  • Experience in automated NGS library preparation

Location: Cambridge, UK

Salary: Competitive + Excellent Benefits

Closing Date: Monday 13th May 2019

If you are interested, please apply.

AstraZeneca is an equal opportunity employer.  AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.