Opportunities for permanent roles in a range of business sectors

Research Associate: Gene editing

4basebio is an innovative gene synthesis company with the ambition to provide high quality, synthetic DNA for use in gene therapy and gene editing platforms. We are expanding our research and development team at our site near Cambridge, UK to facilitate the scaling of our proprietary DNA manufacturing process, develop vectors for DNA delivery and explore gene editing strategies for therapeutic indications. We are looking for dynamic and experienced team members to help us achieve our ambitions and goals.

We are looking for a Research Associate: Gene editing to join our team.


  • Work independently to develop and optimise gene editing strategies for in-house projects
  • Confidently plan, execute, and deliver projects to a high standard and in accordance with project plans
  • Analyse and interpret experimental data; identify and solve experimental problems
  • Drive the evaluation and optimisation of novel gene editing methodologies
  • Deliver gene editing platforms in vitro using non-viral delivery vectors
  • Work collaboratively and support the R&D functions of the Company
  • Attend and participate in relevant meetings, training, and development sessions
  • Use and maintain company equipment in accordance with the company’s SOPs and health & safety guidelines
  • Undertake any other appropriate roles and responsibilities that reasonably fall within the role holder’s skills and experience as requested
  • Be prepared to travel to other 4basebio sites

Essential requirements:

  • PhD or demonstrable equivalent experience in biological sciences, with significant experience in gene editing
  • Extensive knowledge and practical experience in construct design for genome engineering with CRISPR
  • Application of editing strategies in mammalian cell culture, preferably primary cells
  • Extensive practical experience and a good understanding of molecular biology techniques including DNA cloning, DNA, RNA and protein extraction, electrophoresis, qPCR, Western blotting
  • Experience with viral or non-viral delivery vectors, or electroporation
  • Ability to test and troubleshoot new assays and techniques
  • Excellent team working and communication skills

What we offer:
Competitive salary + private healthcare + pension contributions + life assurance

We can only consider candidates who hold the right to work in the UK

To apply for this role, please submit your CV and covering letter