Bioinformatics Lead TICA – TME & IO

AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide.

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines for some of the world’s most serious diseases. At AstraZeneca, we are pioneering new frontiers by identifying and treating patients earlier, working towards the aim of eliminating cancer as a cause of death.

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations, because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people’s exceptional skills with those of people from all over the globe.     

Be part of fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our game-changing pipeline. The vision of AstraZeneca Oncology is to redefine cancer, redefine our solutions to cancer, and restore patients' lives. To achieve this, we have an exciting and diverse portfolio that focuses on four scientific platforms that we believe show the greatest potential for yielding effective medicines for cancer patients. A place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline.

We are seeking a Data Scientist to join the high achieving Tumour & Immune Cell Atlas (TICA) Translational Team. The TICA team delivers a 360° cancer patient and tumour microenvironment view, correlating multi-omics assessment with clinical SOC for prevalence analysis, novel biomarker identification and survival association. This is a well-established team delivering data to inform clinical trial development, combination strategies, competitor drug comparisons and due diligence for new in-licensing opportunities.  In this role you will be accountable for delivery of robust, scientifically driven biomarker data to guide indication selection and identification of targeted patient populations and deliver biomarkers for clinical studies. You will be responsible for applying your strong statistical/analytical skills to the development of novel metrics to discover, design, and implement innovative ways to identify and visualize meaningful patterns in complex data. You will have the opportunity to impact an industry-leading portfolio and provide excellent representation of discovery scientific input to enable successful clinical decisions.

Key Responsibilities and Accountabilities:

  • Accountable for delivery of robust, scientifically driven biomarker data to guide indication selection and identification of targeted patient populations and deliver biomarkers for clinical studies.

  • Responsible for the development of novel metrics to discover, design, and implement innovative ways to identify and visualize meaningful patterns in complex data.

  • Work with our bench scientists to proactively influence the generation of data assets as part of a data generation strategy.

  • Share code and train peers and bench scientists in the tools critical to interpreting complex data.

  • Conduct scientific project meetings to follow progress and present the scientific progress in Translational Medicine leadership meetings, governance boards and in project team meetings and ensure the quality of Translational Medicine clinical study reports, data reviews and interpretations, presentations, scientific publications and recommendations to development teams and management.

  • Lead and champion new innovations within own discipline and assess existing processes and workflows for ongoing technology and/or workflow improvements which will aid the department to meet overall strategic objectives.

Essential Requirements and Qualifications:

  • PhD in Biological Sciences, Computational Biology, Bioinformatics, and/or related fields.

  • Advanced bioinformatic skills (e.g. R programming), proficient in reviewing large scale listings and ability to process large clinical datasets, clinical data review and analysis.

  • Proficient in data handling, data mining, genome analysis, gene signatures identification and generation.

  • Applied knowledge on clinical biostatistics e.g. survival analysis, correlation, feature selection, cross-validation and visualization.

  • Experience contributing to the research community through publication, conferences, and open-source code projects.

  • Strong leadership and oral/written communication skills, interpersonal skills, and ability to multi-task a dynamic portfolio of drug projects and a robust technology development capability.

  • Strong publication record and proven communication and presentation skills to wide audience (specialists and non-specialists).

  • Excellent problem-solving skills with clear understanding of the balance of innovation, smart risks, fit-for-purpose solutions, and timely project delivery.

  • Ability to drive, influence, manage, execute, and deliver results for complex multi-functional, interdisciplinary, and international projects.

  • Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca.

Location: Cambridge, UK

Competitive salary and benefits

Why AstraZeneca?

At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.


So, what’s next?

  • Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.

  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it’s yours.

  • If you’re curious to know more then please reach out to Sophie Halpin.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

Apply now


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