The Sawarkar lab at the MRC Toxicology Unit is looking to appoint a Molecular Cell Biology Research Assistant to contribute to its programme on Epigenetics, Neurodegeneration and Protein Misfolding.
The project will use state-of-the-art genomic technologies to identify epigenetic determinants that lead to protein misfolding in neurons. Using single-cell technologies for in vivo mouse models as well as embryonic stem cell differentiation models of neurodegeneration, the project will identify mechanisms leading to age-associated protein misfolding in neurons.
Your role will be to support the research activities of the group and conduct your own research projects within the remit of the research programme at the frontiers of molecular bioscience.
Candidates will need to be educated to degree level and have appropriate experience (e.g. in vivo biology or physiology or molecular cell biology techniques). You will be able to work both independently and as part of a team, have excellent communication and organisational skills. Enthusiasm for working in a diverse inter-disciplinary team is desirable.
The MRC Toxicology Unit is an internationally renowned institution focused on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities including mass spectrometry, microscopy, and bioinformatics, and offers excellent opportunities for scientific career development.
Further information on the Toxicology Unit can be found at (https://www.mrc-tox.cam.ac.uk)
Rawat P, Boehning M, Hummel B, Aprile-Garcia F, Pandit AS, Eisenhardt N, Khavaran A, Niskanen E, Vos SM, Palvimo JJ, Pichler A, Cramer P, Sawarkar R. (2021) Stress-induced nuclear condensation of NELF drives transcriptional downregulation. Mol Cell. doi: 10.1016/j.molcel.2021.01.016.
Antonova A, Hummel B, Khavaran A, Redhaber D, Aprile Garcia F, Rawat P, Gundel K, Schneck M, Hansen E, Mitschke J, Mittler G, Miething C and Sawarkar R (2019) Heat-shock protein 90 controls the expression of cell-cycle genes by stabilizing metazoan-specific Host-Cell Factor HCFC1. Cell Reports. 29(6):1645-1659.e9.
Fixed-term: This post is funded by the ERC for three years in the first instance, with the possibility of an extension of up to four years.
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