Applications are invited for a researcher position in the laboratory of Dr Paul Miller at the Department of Pharmacology, University of Cambridge. I am looking for a motivated and diligent scientist to study antibody modulators of ion channels and to engineer new research tools. This is vital to define channel subtype contributions to CNS physiology and disease and to discover new therapeutic modalities. This is a great opportunity to gain experience in one or more aspects of handling challenging membrane proteins, structure-guided antibody engineering, and cryo-EM, ideal for follow-on academic and biotechnology careers. The lab utilises mammalian cell protein expression systems, membrane protein purification, and cryo-EM via Arctica and Krios microscopes with K2/K3 direct detectors, and also has manual and automated electrophysiology equipment,. More information about the laboratory is available at https://www.phar.cam.ac.uk/research/miller.
The applicant will be about to obtain a PhD or have obtained a PhD within the last 3 years. Experience in molecular biology, protein production, purification and structural biology (X-ray crystallography or cryo-EM) is required. You must be a careful and methodical worker, paying attention to accuracy, be able to take responsibility and interact as part of a tightly knit team, and be willing to work in a collaborative environment. You should be self-motivated and able to organise, perform and analyse experiments with minimal instruction.
The role holder will be required to relocate to the Cambridge area (if not already resident there). Key duties/responsibilities include: developing research objectives and conducting the research project, writing up research for presentation and publication, continually updating knowledge and understanding in the research field, translating knowledge of advances in the subject area into research activity, managing own research and administrative activities.
The funds for this post are available from approximately 1st October 2022.
Successful candidates who have not been awarded their PhD by the appointment date will be appointed as a Research Assistant at Grade 5 (£27,116 - £31,406). Upon the award of the PhD the individual will be promoted to Research Associate, Grade 7 (£33,309 - £40,927).
Fixed-term: Funds for this post are available for 18-months (with the potential for continuation beyond this).
The Department holds an Athena SWAN bronze award, demonstrating a commitment to provide equal opportunities and to advance the representation of women in science subjects. We welcome applications from all qualified candidates irrespective of gender but, as women are currently under-represented at this level in our department, we strongly encourage applications from female candidates. Appointment will be based on merit alone.
Applications will be assessed as and when they are submitted. Online interviews will take place in late July/early August.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
The online application is to include your personal details, names and addresses of referees, as well as your CV, research publications list and cover letter. Informal enquiries about the position can be made to Dr Paul Miller (email@example.com)
For enquiries about the online application process please contact Debbie Stanley, firstname.lastname@example.org
Please quote reference PL31624 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.