Research Associate Experimentalist (Gottgens Lab)

The University of Cambridge is one of the world's oldest universities and leading academic centres. If you're looking for a new challenge and would like excellent benefits, extensive learning opportunities and a stimulating working environment in return for your skills and contribution, there could be a job here for you.

Applications are invited for the position of Research Associate to join the group of Professor Bertie Gottgens within The Wellcome Trust ¿ Medical Research Council Cambridge Stem Cell Institute and Department of Haematology on the Cambridge Biomedical Campus.

The successful candidates will join a collaborative research team, with the aim to identify the molecular changes that give rise to altered leukaemogenic differentiation landscapes in preleukaemic mouse models. This project will take advantage of state-of-the-art single-cell molecular techniques, genetic perturbations and computational analysis to identify and validate previously unrecognized genes/pathways driving aberrant cell fate decisions in pre-leukemic cells. Experiments will include single cell RNA-seq analysis, perturbation of transcription factors using CRISPR-Cas9, testing of therapeutic compounds, mammalian cell culture, in vitro differentiation assays and in vivo models of leukaemia.

Appointment at Research Associate level is dependent on having a PhD, or an equivalent research doctorate in a relevant subject. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once PhD has been awarded.

The post holder will be expected to participate in the design and planning of experiments. They will be required to perform laboratory-based research and engage effectively with bioinformatic and other project collaborators. The ability to learn quickly and to work both independently and as part of a team is essential. The post-holder will become a valued member of the Gottgens Group and will work alongside students and researchers (both wet and dry). Prior experience of haematopoiesis and leukaemia research, single-cell technologies (such as but not limited to scRNA-Seq), CRISPR editing, viral production, mammalian cell culture (including in vitro differentiation assays and generation of new cell lines), flow cytometry (analysis and sorting), processing of leukemic murine tissues and bioinformatic analysis skills are essential; however, we will consider all the skills and strengths that you have.

Prospective candidates are encouraged to contact Dr Nicola Wilson (nkw22@cam.ac.uk) directly when considering an application to discuss the project in greater detail.

Fixed-term: The funds for this post are available for 18 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a security check.

Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.

Please ensure that you upload a covering letter and a CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.

Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.

The closing date for applications is: 14th January 2024

The interview date for the role is: W/C 22nd January 2024

Please quote reference RB39594 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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