Fixed-term: The funds for this post are available for 1 year in the first instance.
The innate immune response plays an important role in the development of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In particular Toll-like receptor 4 in the cell membrane of cells recognises protein aggregates in solution. This results in the formation of a signalling complex, the Myddosome, leading to the production of pro-inflammatory cytokines.
The aim of this project is to exploit state-of-the-art fluorescence imaging methods developed in the group of Professor Sir David Klenerman, based on fluorescence life sheet imaging, to follow the process of the formation of individual Myddosomes on live macrophage combined with super-resolution imaging of fixed cells to measure the size and structure of the Myddosomes formed ( see our recent papers https://elifesciences.org/articles/31377 and https://pubs.acs.org/doi/10.1021/acs.analchem.0c05296) . These experiments are in close collaboration with the group of Professor Clare Bryant in Clinical Medicine who perform all the cell biology needed for the project.
Applicants are expected to have (or be about to obtain) a PhD in a relevent subject. Experience in both single molecule fluorescence imaging, light sheet imaging and super-resolution microscopy is essential as is experience in building new optical set-ups.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online.
Please ensure that you upload your Curriculum Vitae (CV), a covering letter and publications list in the upload section of the online application. If you upload any additional documents that have not been requested, we will not be able to consider these as part of your application.
For queries relating to your application or the application process, please contact Prof Sir David Klenerman via email on firstname.lastname@example.org
Please quote reference MA39351 on your application and in any correspondence about this vacancy.
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