Senior Scientist, Affinity Reagents (B-cell), Discovery Platforms , Biologics Engineering

AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide.

Do you have expertise in antibody discovery and B-cell technologies? Are you keen to apply your knowledge and skills to enhance our internal platforms, and discover reagent antibodies crucial to drug discovery programmes? Do you want to work in a company that follows the science and turns ideas into life changing medicines? Then this role at AstraZeneca might be the one for you!

About AstraZeneca

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means thinking big and working together to make the impossible a reality.

Site description

The role is based in our new pioneering Discovery Centre (DISC) located on the Cambridge Biomedical Campus. This newly purpose-built building that will bring together the company’s research and development activity in a pioneering strategic R&D centre and global corporate headquarters. The building has been designed with the open architecture reflecting AstraZeneca’s approach to research. Open laboratories and glass walls will enable new ways of working across teams, whilst a central courtyard will put science on full display.

Business area

In the Oncology Business Unit we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease. Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, questioning accepted norms, quick decision-making and doing things differently. A place of trust, it’s an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. This is the time to join the team who is confident that cures for cancer are within our grasp.

What you'll do

We are seeking a highly motivated and independent Senior Scientist to join the Affinity Reagents Team, part of Discovery Platforms within Biologics Engineering. You will play a key role utilising and developing our B cell platform, to deliver high quality novel reagents, supporting the progression of diverse discovery pipeline projects in a range of therapeutic areas. The successful candidate will add to a team of multidisciplinary and passionate scientists excited by innovative research.

Essential for the role

  • PhD in immunology, molecular / cell biology or related discipline, or BSc with significant relevant lab-based experience

  • Ability to independently design and execute diverse in vivo antibody discovery campaigns, including immunisation and screening strategies

  • Experience and track-record working with flow cytometry and/or FACS, (ideally immune cells)

  • Strong molecular biology (e.g., PCR, RT-PCR, ligation-dependent and independent cloning, site-directed mutagenesis, Sanger sequencing/analysis)

  • Experience with antibody screening and characterisation methods (e.g. ELISA, SPR, BLI or flow cytometry)

  • Solid theoretical knowledge of antibody sequence analysis (e.g. annotation, clustering)

  • Ability to optimize protocols, troubleshoot, interpret experimental results and maintain accurate, high quality and up-to-date records

  • Ability to work collaboratively in order to achieve objectives, as demonstrated by publications

  • Documented proficiency in the English language, both writing and speaking

Desirable for the role

  • Experience with in vitro display and/or antibody engineering

  • Experience with next-generation sequencing (NGS)

  • Experience of project management, working in a matrix environment and outsourcing

So, what’s next?

  • Are you already envisioning yourself joining the team? Good, because we can’t wait to hear from you.

Competitive salary package and benefits

Close Date: 08/01/2024

Where can I find out more?

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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