Senior Scientist - Assay Development

We are continuing to grow our biology team and are now seeking an assay development scientist with hands-on experience in designing and testing molecular and cellular assay formats.  

Our mission is to push the boundaries of complex cell analysis. Using the Lightcast platform we are working with major pharmaceutical companies and leading academic institutes. Together, using our next generation microfluidic platform, we are making advances towards new science, unique clinical approaches, new therapies and innovative products.

The Lightcast platform allows precise and highly flexible independent control of thousands of microdroplets independently and in parallel using software-generated light patterns. By combining droplets containing different cells, antibodies, cancer drugs, reporters and /or other reagents we can perform complex workflows and assays with a flexibility far beyond what is currently possible on any cell analysis platform. 

We are continuing to grow our biology team and are now seeking an assay development scientist with hands-on experience in designing and testing molecular and cellular assay formats.  

 At Lightcast we are developing a next generation microfluidic platform that uses software-generated light patterns to precisely manipulate thousands of individual cell- and reagent-containing microdroplets independently and in parallel on-a-chip. 

 As a key team member, you will drive the translation of molecular and cellular assays to the very unique environment of the Lightcast platform. You will be responsible for optimising the performance of existing and design novel assays down to single cell and picolitre perfromance. As part of this work, you will establish reference bench assays and adapt them for use on the Lightcast platform. As your work will contribute to the efforts of a multi-functional team, you will also communicate closely with software and instrument development scientists to feedback on requirements for on-chip controls and analysis tools as the system evolves towards higher throughput. 

 Your responsibilities will include 

  • Designing and testing benchmarking assays for the adaptation of molecular and cellular assays to the Lightcast platform 
  • Optimising assay formats for use at single cell/small volume level 
  • Keeping up to date with new assay technologies that could be applied to the Lightcast platform 
  • Working hand-in-hand with the team of cell and molecular biologists, software developers and microfluidics engineers to define appropriately controlled workflows on-chip 
  • In close communication with the quality team, develop assays in line with verification and validation requirements 
  • Liase with and coordinate 3rd parties for potential combined assay development 

 Collaboration and planning   

  • Participate in team technical discussions and problem-solving exercises  
  • Support other team members and their projects/mentor junior members of the bio team 
  • Contribute to technical meetings  
  • Contribute to work plans and test designs  
  • Contribute to meetings with external collaborators  

 Communication and documentation  

  • Generate SOPs, experimental plans and result reports 
  • Prepare presentations and reports for audiences inside and outside the company, including for collaborators and clients  

We would expect you to have:   

  • A PhD in biochemistry or a similar field plus a minimum of 2 years lab-based postdoctoral experience in academia or industry  
  • Or an MSc with 7+ years of relevant experience 
  • A first-class or 2:1 degree in biochemistry or similar 
  • Strong background in biochemical assays, molecular assays and in vitro phenotyping techniques  
  • Proven track record in development and validation of molecular and cellular assays with a range of readouts formats  
  • Experience with use of relevant software/analysis strategies to interpret assay data with respect to sensitivity, specificity, range, stability, reproducibility and precision 
  • Demonstrable experience with interdisciplinary and cross-functional working  
  • Exceptional problem-solving skills  
  • Excellent communication skills, ability to relate complex scientific concepts in a clear and concise manner  
  • Experience of independent, self-directed work, excellent organizational and record keeping skills 

 Advantageous experience  

  • Single cell/single molecule assay formats 
  • Microfluidics/ in-droplet assay formats 
  • No wash assays
  • Optimisation of bead-based assays 
  • High throughput assays 
  • Experience with downstream -omics techniques 
  • Assay development under ISO 13485, or similar (ISO17025, GLP, GCP and GMP) 

Applicants must be eligible to work in the UK. 

Lightcast Discovery offer competitive salaries and comprehensive benefits including:  

  • 26 days holiday, plus Public Holidays  
  • Flexible working hours  
  • Share option scheme
  • Private medical insurance 
  • Income protection 
  • Life insurance 
  • Subsidised gym membership and weekly cross fit sessions
  • Access to Cycle to Work and Technology schemes 
  • Enhanced family leave policies  
  • Plus more…. 

Here at Lightcast Discovery we have an informal, open work environment where collaboration and innovation are at the heart of what we do.  We’re based in West Cambridge, near excellent transport links and plenty of local amenities.  We regularly gather as a team to hear about developments across functions and to share ideas.  We enjoy social events and regular team lunches, promote  career development and learning opportunities.  It’s an exciting time to join our revolutionary team as we push boundaries and continue to grow.        

 We aim to be an equal opportunities employer and we are determined to ensure that no applicant or employee receives less favourable treatment on the grounds of gender, age, disability, religion, belief, sexual orientation, marital status, or race, or is disadvantaged by conditions or requirements which cannot be shown to be justifiable. 

 Strictly no agencies please 


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