Senior Scientist – Project Analytical Chemistry lead

AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide.

Macclesfield (UK)

Date opens: 28/11/2023

Date closing: 07/01/2024

We are an expanding group looking for strong analytical scientists to join a vibrant team, working on the next generation of medicines. You will be responsible for using science and innovation to deliver analytical knowledge that encompasses understanding of analytical and regulatory control strategy during the development of late phase through to commercial. You will be able to work independently and lead interactions within multi-functional teams, including Process Chemists, Engineers, Contract Manufacturing Organisations (CMOs), Pharmaceutical Product Development, Regulatory CMC, Quality Assurance and Supply Chain.

Pharmaceutical Technology and Development (PT&D) are the bridge, which turns brilliant science into medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices required to support new medicines – from supplies for use in early toxicology studies and clinical trials to developing the technology to ensure drugs can be scaled up for commercial manufacture.

Key responsibilities:

  • As a project analyst, you will work closely with process chemists, engineers, project managers and other scientists, you will contribute to pharmaceutical development programmes, supporting project progression through late clinical development and launch.
  • You will lead key activities connected to the control strategy development programme, as well as directing the work of other scientists.
  • You will lead analytical activities across the route of manufacture to API, to support project learning and progression from clinical development phases through to late development and commercialisation
  • The development of API analytical control strategies, including structural characterisation, specification setting, impurity control and stability understanding.
  • Identifying and solving potential analytical project issues
  • Planning and conducting lab-based experimental work in accordance with project timelines
  • Supporting the technical development of other scientists
  • Collaborating with internal and external manufacturing partners to deliver the analytical aspects of GMP API manufacture
  • Staying ahead of scientific developments and proactively applying existing and novel approaches to projects
  • Authoring the CMC components of regulatory submissions and preparation of successful regulatory responses

Required Qualifications, Skills, Knowledge and Experience

  • A degree (BSc, MSc or equivalent) in Chemistry or Analytical Chemistry with a proven track record of analytical development in a pharmaceutical environment, or a PhD including aspects of analytical measurement.
  • Knowledge and practical experience across a range of analytical techniques including liquid and gas chromatography, mass spectrometry and Nuclear Magnetic Resonance (NMR).
  • Scientific leadership skills and the ability to use knowledge and experience to assess options available and deliver robust scientific contributions to projects
  • Strong problem-solving skills, underpinned by strong practical laboratory experience
  • Experience of working collaboratively within a mixed skill technical team and ability to develop and utilise networks
  • Ability to communicate complex scientific information in a clear, concise and understandable way

Desirable Skills, Knowledge and Experience

  • Ability to confidently and successfully lead improvement projects
  • Strong influencing, planning and prioritisation skills to ensure project delivery to deadlines
  • Experience of leading technical teams, coaching and people development
  • Commitment to improvement and innovation and knowledge of Lean principles
  • Knowledge and practical experience of quality and regulatory requirements (GMP and ICH) and health and safety requirements

How to Apply

To be considered for this exciting opportunity, please complete the full application form on our website. Applications must include your current CV and a covering letter, which presents your motivation for applying and suitability for the role.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working give us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of five days per week from the office. But that doesn’t mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca?

At AstraZeneca, we 're dedicated to being an outstanding Place to Work. Where you are empowered to push the boundaries of science and spark your high-reaching spirit. There’s no better place to make a difference to medicine, patients, and society. An inclusive culture that champions diversity and partnership, and always committed to lifelong learning, growth, and development. We’re on an exciting journey to pioneer the future of healthcare.

Are you ready to bring new insights and fresh thinking to the table, Brilliant! We have one seat available, and we hope it’s yours.

Competitive salary and benefits.

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

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