Walk-away process development with Syrris’ Atlas reactors


27-03-2019

Researchers at TauRx Therapeutics are using the automation capabilities of the Syrris Atlas HD reactor systems to simplify and accelerate process development for its product pipeline.

Based at the company’s primary research facilities at the University of Aberdeen, Scotland, the Syrris equipment is an integral part of the quality by design (QBD) process optimization workflow. Process Chemist Scott Clunas explained: “We have been using Syrris’ Altas Syringe Pumps and software for a number of years. This combination of pumps and automation software is very flexible, allowing us to add multiple reagents to a reactor vessel at set intervals, without needing to have somebody at the bench to manually add liquids or swap lines. We have been very happy with the robustness and performance of the pumps, so when we were looking to invest in additional batch reactor systems, Syrris was the logical choice.

“We now have four Atlas HD jacketed reactor systems – set up as two parallel pairs each controlled by a single PC – allowing us to more quickly and easily perform QBD studies for the production of our active pharmaceutical ingredients. Each of these experiments can run for 24 to 48 hours, so it’s essential that we can automate the entire reaction. The Atlas reactor systems ensure that each experiment is performed in exactly the same way every time – eliminating the variability associated with manual processes – giving us a very high degree of process control for consistent results and, ultimately, more robust processes,” Scott concluded.

About Syrris Limited

Syrris develops laboratory automation products for research and development chemists, and is renowned for its batch chemistry reactors and world-leading flow chemistry systems. It offers advanced lab-scale reactor systems – including the Atlas batch reactor, the fully automated Atlas HD system and the manually operated Orb jacketed reactor platform – as well as the Asia flow chemistry systems. The company’s latest innovations include the Orb Pilot large-scale batch reactor and the Titan continuous flow chemical processing systems.

In recognition of its technological achievements, Syrris received the eastern region’s UKTI Best Established Exporter award, as well as the award for the Most Outstanding Export Achievement at the Global Opportunity Conference on International Trade. In 2012, its Asia Flow Chemistry system was the recipient of a prestigious R&D award.

Established in 2001, Syrris is a brand of Blacktrace Holdings Ltd, a world leader in Productizing Science®. The company is based in Royston, near Cambridge, UK, where it employs 125 staff – including 40 chemists and engineers – with offices in the US, Japan, India and Brazil, as well as more than 45 distributors worldwide.

To find out more about Syrris, please visit www.syrris.com

 

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