Depression trial prompts call for funding boost

still from video featuring Dr Golam Khandaker

More needs to be invested in mental health to find new treatments, since around a third of patients do not respond to anti-depressants currently available.

That is the message from an honorary Cambridge University Hospitals NHS Foundation Trust (CUH) consultant psychiatrist who says we “desperately need better outcomes for patients”.

Dr Golam Khandaker, chief investigator of an ongoing clinical trial called The Insight Study, spoke in a video just posted on social media about his work with fellow members of Cambridge-based Inflammation and Psychiatry Research Group, Dr Joel Parkinson and research assistants, Bianca Oltean and Eimear Foley.

He explains how they are investigating an anti-inflammatory drug called tocilizumab, commonly used to treat arthritis, which may help some of the millions of people worldwide who suffer from depression.

Research suggests that low grade inflammation – or over-activity of one aspect of the immune system – may play a role in the development and persistence of depression.

The study is being run at CUH and is organised by the University of Cambridge and Cambridgeshire and Peterborough NHS Foundation Trust, with support from the Wellcome Trust and the BMA Foundation. Insight is also supported by the National Institute for Health Research Clinical Research Network (NIHR CRN) eastern.

Participants receive an intravenous infusion at the NIHR Cambridge Clinical Research Facility of either tocilizumab or a dummy drug at have their pulse and blood pressure checked, and answer questions on how they feel. Follow-up research visits takes place at week one, two and four after infusion.

The group investigates links between the immune system and neuropsychiatric brain disorders, particularly depression and schizophrenia. The aim is to identify novel treatments.

Dr Khandaker, a BMA Foundation for Medical Research J Moulton grant winner, said: “In our lifetime about 20 per cent of people will suffer from major depression.

“Charities play a crucial role in funding biomedical research in this country.  We need to invest more in mental health research because we desperately need more treatments.

“With the help of this new J Moulton grant we will be able to do more new immunological assays to pin down the exact mechanisms of antidepressant effect of this drug.

“If this study shows that anti-inflammatory drugs improve mood, that could make a huge impact for thousands, if not millions of people, who suffer from these conditions.”

The Insight study is currently looking for participants. Anyone interested in supporting, or taking part in the study, should contact the study team by emailing at or by telephoning 01223 768 510.

For more information about the study and to register your interest online, visit:

View the video here>>>

Recruitment in the Insight study will continue until the end of 2020.


Cambridge University Hospitals is one of the largest and best known trusts in the country. As the local hospital for our community we deliver care through Addenbrooke’s and the Rosie hospitals.

Cambridge University Hospitals NHS Foundation Trust