Today, UKRI and NIHR are announcing £8.4 million funding for one of the world’s largest studies into the long-term physical and mental health impacts of coronavirus on hospitalised patients. Results from the UK-wide study will inform the development of new and better measures to treat and rehabilitate patients hospitalised with COVID-19.
World-leading study into long-term health impacts of COVID-19 launched by UKRI and NIHR
Around 10,000 patients are expected to take part in the ground-breaking new study, led by the NIHR Leicester Biomedical Research Centre, a partnership between the University of Leicester and the University Hospitals of Leicester NHS Trust. The Post-HOSPitalisation COVID-19 (PHOSP-COVID) study will draw on expertise from a consortium of leading researchers and doctors from across the UK.
Symptoms of Covid-19 have varied among those who have tested positive: some have displayed no symptoms, while others have developed severe pneumonia and, tragically, have even lost their lives.
For those who were hospitalised and have since been discharged, it is not yet clear what their medical, psychological and rehabilitation needs will be to enable them to make as full a recovery as possible.
The PHOSP-COVID study will assess the impact of Covid-19 on patient health and their recovery. This includes looking at possible ways to help improve the mental health of patients hospitalised with coronavirus, and how individual characteristics influence recovery, such as gender or ethnicity.
Patients on the study from across the UK will be assessed using techniques such as advanced imaging, data collection and analysis of blood and lung samples, creating a comprehensive picture of the impact Covid-19 has on longer term health outcomes.
The findings will support the development of new strategies for clinical and rehabilitation care, including personalised treatments based on the particular disease characteristics that a patient shows, to improve their long-term health.
Health and Social Care Secretary Matt Hancock said: “As we continue our fight against this global pandemic, we are learning more and more about the impact the disease can have not only on immediate health, but longer-term physical and mental health too.
“This world-leading study is another fantastic contribution from the UK's world-leading life sciences and research sector. It will also help to ensure future treatment can be tailored as much as possible to the person.”
UK Research and Innovation Chief Executive, Professor Ottoline Leyser, said: “We have much to learn about the long-term health impacts of COVID-19 and its management in hospital, including the effects of debilitating lung and heart conditions, fatigue, trauma and the mental health and wellbeing of patients.
“UKRI is collaborating with NIHR to fund one of the world’s largest studies to track the long-term effects of the virus after hospital treatment, recognising that for many people survival may be just the start of a long road to recovery.
“This study will support the development of better care and rehabilitation and, we hope, improve the lives of survivors.”
Chief Medical Officer and Head of NIHR Professor Chris Whitty said: “As well as the immediate health impacts of the virus it is also important to look at the longer-term impacts on health, which may be significant.
“We have rightly focused on mortality, and what the UK can do straight away to protect lives, but we should also look at how Covid-19 impacts on the health of people after they have recovered from the immediate disease.
“This UKRI and NIHR funded study is one of the first steps in doing this.”
Chris Brightling, Professor of Respiratory Medicine at the University of Leicester, Consultant Respiratory Physician at Leicester’s Hospitals and Chief Investigator said: “As we emerge from the first wave of the pandemic, we have new insights into the acute phase of this disease but very little information about patients’ long-term needs.
“It is vitally important that we rapidly gather evidence on the longer term consequences of contracting severe COVID-19 so we can develop and test new treatment strategies for them and other people affected by future waves of the disease.”
The recruitment process for patients has been designed to ensure the best representation of those hospitalised with coronavirus, with a team of experts that have worked extensively on optimising inclusion and recruitment of underrepresented groups. The patients are expected to start being recruited by the end of July.
This study builds on the UK’s existing large and successful studies for hospitalised Covid-19 patients, funded by UKRI and NIHR, including the RECOVERY trial (which identified the first drug to reduce COVID-19 deaths in hospitalised COVID-19 patients, dexamethasone) and ISARIC-4C.
The Medical Research Council has been at the forefront of scientific discovery to improve human health. Founded in 1913 to tackle tuberculosis, the MRC now invests taxpayers’ money in some of the best medical research in the world across every area of health.