In recent years, biocompatible nanostructured materials have emerged as promising delivery systems for anticancer drugs, DNA and imaging agents. Specifically, colloidal gold nanoparticles (GNPs) with their fine tunable optical and electrical properties, allow implementations in cancer diagnosis and photothermal therapy. GNPs are able to convert adsorbed light into localized thermal energy via surface plasmon resonance mechanism and ablates targeted solid tumors [1-2].
Conventional spherical GNPs display wavelength adsorption between 500-550 nm which is insufficient for tissue penetration. However, gold nanorods (GNRs), due to the morphological aspect ratio, show near-IR absorbing properties from about 700 to 800 nm which boosts their value in photothermal cancer therapy [2].
The most common synthetic method of GNRs involves cetyltrimethylammonium bromide (CTAB) for colloidal stabilization. This material is a major barrier in the application of GNR-based materials, especially for in-vivo applications. CTAB is a cytotoxic material which is why its removal from the particle surface is one of the primary challenges. It is believed that complete removal of CTAB from GNRs will ultimately lead to the best cell viability of the GNRs [3-4].
In collaboration with SONA Nanotech, Strem Chemicals presents CTAB free GNRs designed for life sciences and specifically in-vivo human applications:
Catalog # |
Name |
Axial Diameter |
Wavelength |
Gold Gemini Nanorods; CTAB Free |
13-18 nm |
650 nm |
|
Gold Gemini Nanorods; CTAB Free |
13-18 nm |
700 nm |
|
Gold Gemini Nanorods; CTAB Free |
10-13 nm |
750 nm |
|
Gold Gemini Nanorods; CTAB Free |
10-13 nm |
800 nm |
|
Gold Gemini Nanorods; CTAB Free |
9-12 nm |
850 nm |
GNRs, with tunable electro-optical properties and controlled with minimum amount of surfactants, allow their application not only for certain biomedical properties, but also for colorimetric and fluorescent detections, imaging macrophage activity, electrochemical gas sensing/biosensing and catalytic application [5-7]. Strem Chemicals also offers ascorbic acid and CTAB stabilized gold nanorods:
Catalog # |
Name |
Axial Diameter |
Wavelength |
Gold Nanorods; contains CTAB |
Aspect Ratio: 3-3.5 |
680 nm |
|
Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB |
25 nm |
550 nm |
|
Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB |
25 nm |
600 nm |
|
Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB |
25 nm |
650 nm |
|
Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB |
25 nm |
700 nm |
|
Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB |
10 nm |
700 nm |
|
Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB |
10 nm |
750 nm |
|
Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB |
10 nm |
780 nm |
|
Gold Nanorods; < 0.1% ascorbic acid, < 0.1% CTAB |
10 nm |
808 nm |
In addition, Strem Chemicals offers three different gold nanorod kits.
Catalog # |
Name |
Gold Gemini Nanorods Kit, CTAB Free (Wavelength 650-850 nm) |
|
Gold Nanorods Kit (Axial Diameter - 25 nm, wavelength 550-700 nm) |
|
Gold Nanorods Kit (Axial Diameter - 10 nm, wavelength 700-808 nm) |
References:
- E. Carrasco et al. Adv. Funct. Mater. 2015, 25, 615-626
- Lakhani et al, Nanotechnology 26 (2015) 432001 and references are therein
- C. Kinnear et al. Angew. Chem. Intern. Ed., 2014, 53, 12613-12617.
- L. Vigderman et al.Angew. Chem. Int. Ed. 2012, 51, 636-641.
- J. Olson et al. Chem. Soc. Rev., 2015, 44, 40-57
- M Baaske et al; Nature Nanotechnology, 2014, 9, 933-939
- Bo et al, ACS Nano, 2013, 7, 5993-6000
Visit the below link to view additional details on our website: Gold Nanorods Synthesized without CTAB
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