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3-year PhD Fellowship, Innovative Training Network BonePainII

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AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide.

3-year PhD Fellowship,  Innovative Training Network BonePainII

Cambridge, UK

Salary Competitive

We have 1 open position for a 3-year PhD fellowship in the EU-funded Innovative Training Network BonePainII (www.bonepain.eu). The PhD position will be a collaboration between AstraZeneca, University College London (where the student will be registered for their PhD) and The Royal Veterinary College.

Expected starting date June 1, 2019

About the BonePainII Network

BonePainII is a European Innovative Training Network to promote frontline research, innovation and education within bone pain. Millions in Europe and beyond suffer from bone pain, which is a debilitating complication of many musculoskeletal disorders such as arthritis and bone metastasis. The BonePainII network has participants from 6 European countries and encompasses 8 academic groups and 4 industries all committed to creating an outstanding training program for 15 early stage researchers (ESRs) to elucidate the mechanisms of bone pain and develop new medicines.

The project is funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 814244.

Project title: Comparative face, construct and predictive validity of CFA and bone loading models of osteoarthritis
You will be participating in a programme of work to help us better understand models of osteoarthritis. Currently, the power of existing models to predict clinical outcomes in modulating osteoarthritis pain are not well understood- combining in vivo behavioural endpoints, with histopathological and pharmacological analysis may help us to understand whether a new model of OA, the bone loading model, will represent the known pharmacology and histopathology of clinical osteoarthritis, and you will compare this to an established model. You will also learn about different measurement endpoints in models of OA, and gain insight into how such models are used in the drug discovery and development process.

Required qualifications
The successful candidate must hold a relevant BSc or MSc degree. Experience with in vivo techniques will be an advantage.

General role description
Your key tasks as a PhD fellow are to:
• Manage and carry through your research project
• Participate in the BonePainII training and network activities
• Take PhD courses
• Write scientific articles and your PhD thesis
• Participate in national and international congresses and scientific meetings
• Research stay at an external research laboratory within the BonePainII network
• Disseminate your research  

Key criteria for the assessment of applicants
• Relevant skills and knowledge
• Previous publications
• Relevant work experience
• The grades achieved during bachelor/master studies
• Other professional activities
• Language skills
• Assessment of the candidate’s motivation letter

Formal requirements: Mobility and eligibility criteria
The candidate must not have resided or carried out his/her main activity (work, studies, etc.) in the country of his/her host organization for more than 12 months in the last 3 years immediately prior to his/her recruitment – unless as part of a procedure for obtaining refugee status under the Geneva Convention.

The candidate must be an Early-Stage Researcher (ESR): at the date of recruitment he/she must be in the first four years (full-time equivalent research experience) of his/her research career and must not have not been awarded a doctoral degree.

Terms of employment
The terms of employment and salary are in accordance with the local and national rules and in accordance to the rules and regulations laid down by the European Union’s Horizon2020 Marie Sklodowska-Curie Action European Training Network. Exact salary will be confirmed upon appointment.

How to apply
• Cover letter: Letter stating the interest in and qualifications for the project (max. one page).
• Full CV including list of publications

• For shortlisted applicants, we will require 2 letters of recommendation including contact details for references.

• For those applicants whose principal language of instruction during their BSc/MSc was not English it will be an advantage if they enclose IELTS or TOEFL test scores or equivalent proof of English skills.

Applications open: 1st April 2019

Deadline for applications: 30th April 2019

Applications will be evaluated by an assessment committee consisting of the principal supervisor and 1-2 other members of the BonePainII network or the Department. Short-listed candidates will be invited for an interview (e.g. via Skype). In case of highly qualified, but unsuccessful applications, applicants might have the choice of having their application forwarded to another suitable BonePain network member for consideration.

AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, gender or gender orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.

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