Upside down and inside out

Researchers have captured the first 3D video of a living algal embryo turning itself inside out, from a sphere to a mushroom shape and back again. The results could help unravel the mechanical processes at work during a similar process in animals, which has been called the “most important time in your life."

 

This simple organism may provide ground-breaking information to help us understand similar processes in many different types of animals.
    - Stephanie Höhn

Researchers from the University of Cambridge have captured the first three-dimensional images of a live embryo turning itself inside out. The images, of embryos of a green alga called Volvox, make an ideal test case to understand how a remarkably similar process works in early animal development.

Using fluorescence microscopy to observe the Volvox embryos, the researchers were able to test a mathematical model of morphogenesis – the origin and development of an organism’s structure and form – and understand how the shape of cells drives the process of inversion, when the embryo turns itself from a sphere to a mushroom shape and back again. Their findings are published in the journal Physical Review Letters.


Watch the video and read the full story


Image: Adult Volvox spheroid containing multiple embryos
Credit: Stephanie Höhn, Aurelia Honerkamp-Smith and Raymond E. Goldstein

Reproduced courtesy of the University of Cambridge
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