Conduct disorder is a complex behavioural disorder, so we would expect the changes to be more complex in nature and to potentially involve other brain regions.
- Luca Passamonti
In a study published in the Journal of Child Psychology and Psychiatry, researchers used magnetic resonance imaging (MRI) methods to look at the brain structure of male adolescents and young adults who had been diagnosed with conduct disorder – persistent behavioural problems including aggressive and destructive behaviour, lying and stealing, and for older children, weapon use or staying out all night.
In particular, the researchers looked at the coordinated development of different brain regions by studying whether they were similar or different in terms of thickness. Regions that develop at similar rates would be expected to show similar patterns of cortical thickness, for example.
“There’s evidence already of differences in the brains of individuals with serious behavioural problems, but this is often simplistic and only focused on regions such as the amygdala, which we know is important for emotional behaviour,” explains Dr Luca Passamonti from the Department of Clinical Neurosciences at the University of Cambridge. “But conduct disorder is a complex behavioural disorder, so likewise we would expect the changes to be more complex in nature and to potentially involve other brain regions.”
In a study funded by the Wellcome Trust and the Medical Research Council, researchers at the University of Cambridge recruited 58 male adolescents and young adults with conduct disorder and 25 typically-developing controls, all aged between 16 and 21 years. The researchers divided the individuals with conduct disorder according to whether they displayed childhood-onset conduct disorder or adolescent-onset conduct disorder.
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Image: The orbitofrontal cortex (blue) and medial temporal cortex (red) were more similar in terms of thickness in youths with Conduct Disorder than in typically-developing youths, suggesting that the normal pattern of brain development is disrupted.
Credit: Nicola Toschi
Reproduced courtesy of the University of Cambridge
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