So you've read '50 Shades of Grey', time now perhaps to read '50 Shades of Saliva'

We've all heard of Christian Grey and his 50 shades of grey. But how much do you know about saliva? Here Salimetrics lists 50 informational, interesting and amazing facts about saliva that even Mr. Grey didn’t know!

If you know more, please tell us: [email protected]



50 Shades of Saliva

  • An adult human being can produce up to 1.5L of saliva per day
  • Saliva is produced by 3 big glands (parotids, submandibulars and sublinguals) and several hundreds of smaller glands
  • The submandibular glands produce biggest amount of saliva
  • Saliva consists of approximately 99% water containing a variety of electrolytes and proteins, such as enzymes, immunoglobulins and glycoproteins
  • Saliva production decreases during the night to a minimum
  • Patients with Sjogren’s syndrome suffer from severe xerostomia, the medical term for dry mouth
  • Over 500 of prescription medication can reduce salivary flow
  • An average human produces enough saliva over their lifetime to fill up 2 swimming pools
  • Saliva production increases after consumption of spicy, sour or acidic foods
  • There are more than 250 different species of bacteria in the mouth
  • Saliva flow rate can be increased using a chewing gum, citrus fruits and even marshmallows
  • Parasympathetic stimulation results in watery thin saliva whereas sympathetic stimulation leads to viscous saliva which is high in protein
  • Liquorice and grapefruit juice can interact with and increase cortisol availability
  • Excessive drooling can be a sign for teething in babies
  • Sport scientists around the world are monitoring salivary analytes to monitor and improve human performance
  • Cortisol is also known as compound F
  • You produce more saliva just before vomiting as part of a bodily reflex
  • The oral compartment is one of the most diverse biological microenvironments in the body
  • Saliva contains the natural analgesic opiorphin, which is 6 times more potent than morphine
  • Glycoproteins in the pellicle inhibit bacterial adhesion to the tooth surface and reduce the erosive potential of coke by up to 50%
  • You cannot taste food unless it is mixed with saliva
  • There are approximately 3000 published papers on salivary cortisol
  • Sodium Bicarbonate in saliva helps to neutralize tooth enamel damaging acids in foods and drinks
  • It is a myth that a dog’s mouth is cleaner than a human’s mouth.
  • The bite of a leech does not hurt because its saliva numbs the area
  • Spittoons are frequently used by wine tasters
  • Salimetrics was founded in 1998 because the immunodiagnostic industry did not realize the potential of saliva as a research and diagnostic specimen
  • Saliva contains molecules that aid in wound healing; a possible reason why animals lick their wounds
  • Saliva reduces tooth decay and infection by washing away food particles and bacteria
  • Human saliva contains antibacterial agents such as secretory IgA, Lactoferrin, lysozyme and peroxidase
  • Injuries in your mouth heal much faster than in other areas of your body
  • Increased levels of salivary C-reactive protein might indicate a risk of heart disease
  • The aerodramus nests, built from spit, are prized for use in bird’s nest soup, one of the most expensive dishes in the Chinese cuisine
  • Swallowing saliva stimulates gastric secretion
  • Public education campaigns in China aimed to reduce public spitting ahead of the 2008 Olympic Games in Beijing
  • DNA extracted from saliva is often used in criminal investigations
  • Salivary cotinine measurements might be conducted by health and life insurance companies in order to determine tobacco use
  • Public spitting can result in fines and even jail time in many countries
  • Salivary estradiol measurements can be used to replace daily blood tests in infertility treatment
  • Contrary to rumours, llamas rarely spit at humans
  • In the last few years more than 150 peer reviewed articles have been published exploring salivary alpha amylase
  • Studies have collected saliva from dogs, horses, wolves, antelopes, gorillas, rats, sea lions…
  • According to anthropologists, men’s preference for sloppier kisses is due to the subconscious transfer of salivary testosterone to women
  • The soul singer Lisa Stansfield was allergic to her own saliva
  • One millilitre of saliva contains approximately 100 000 000 bacteria
  • According to Masai mythology, a Masai spits slightly several times on a baby that he has never seen before
  • Hedgehogs produce large amountsof foamy saliva when they encounter an unfamiliar smell
  • Salivary cortisol measurements are used to monitor metabolic disorders such as Addison’s Disease and Cushing’s syndrome
  • Saliva can be used to test for use of illicit drugs, such as THC, cocaine and amphetamines
  • Salivary flow is lower when we are sitting than when standing



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