Key human bladder cancer genes pinpointed in cats and dogs
Key bladder cancer genes have been uncovered through studying the cancers in cats and dogs, in a significant stride for finding which of many mutations are the most important in the cancer’s development.
Cambridge students team up with Sanger Institute to develop a hub of biodiversity
A team of learners at Cambridge Regional College has been busy creating a centre of biodiversity at the college’s site in Cambridge. The Darwin Tree of Life community project, launched in collaboration with the Wellcome Sanger Institute in September 2022, has been working to measure the variety of plants, animals and insects present on the campus.
New tool tracks individual immune cell development
A new tool that can uncover the developmental history of certain immune cells is now freely available worldwide. The tool provides insights into the stages that immune cells go through in a healthy individual and how this can be impacted in disease.
Machine learning helps determine success of advanced genome editing
A new tool to predict the chances of successfully inserting a gene-edited sequence of DNA into the genome of a cell, using a technique known as prime editing, has been developed by researchers at the Wellcome Sanger Institute.
Spatial lung cell atlas offers insights into disease and immune function
The most comprehensive lung cell atlas to date, from the Wellcome Sanger Institute and collaborators, has revealed 11 new lung cell types and offers detailed insight into an immune process involved in fighting lung infections.
Breast cancer spread uncovered by new molecular microscopy
New technology can trace which populations of breast cancer cells are responsible for the spread of the disease, and for the first time highlights how the location of cancer cells could be as important as mutations in tumour growth.
Rapid immune response in children protects them from COVID-19, genetic study finds
Fundamental differences in the immune response of adults and children can help to explain why children are much less likely to become seriously ill from SARS-CoV-2, according to new research from the Wellcome Sanger Institute, University College London and their collaborators.
New centre to foster global conversations about ethical issues raised by science
The University of Cambridge and Wellcome Connecting Science announce the launch of the Kavli Centre for Ethics, Science, and the Public, to engage publics and scientists with the ethical implications of scientific discovery and its impact on society.
Sanger Institute launches Fellowship programme to support next generation of Black scientists
The Wellcome Sanger Institute has today (8 December) launched the Sanger Excellence Postdoctoral Fellowship − a Fellowship designed to support the training and career development of scientists from Black backgrounds.
Human parasite’s daily rhythms could be targeted for better treatments
For the first time, the worm that causes schistosomiasis has been shown to have a daily rhythm that impacts which genes are switched on at different times.
Uterus study is important step towards understanding diseases that affect one third of women
The most comprehensive cell atlas to date of the human uterus has identified two new epithelial cell states that can be used to distinguish two forms of uterine cancer. Researchers from the Wellcome Sanger Institute, the University of Cambridge and their collaborators also identified the genetic pathways that determine two main endometrial cell types.
Sanger celebrates Highly Cited Researchers
A number of researchers from the Wellcome Sanger Institute have been named on Clarivate's Highly Cited list.
Researchers will map immune cells across Latin America with support from CZI
A new grant awarded to the Wellcome Sanger Institute and international collaborators within seven Latin American countries by the Chan Zuckerberg Initiative (CZI) will fund the first high-resolution genetic atlas of immune cells in Latin America, uncovering new information about health and disease.
Sanger researchers to tackle deadly brain cancer with ‘tissue time machine’
Sanger Institute scientists are starting a new project that will integrate information from spatial transcriptomics with single-cell RNA and DNA sequencing, to understand how brain cancer develops.
New database of 660,000 assembled bacterial genomes sheds light on the evolution of bacteria
A vast, curated collection of bacterial genomes has been created that allows the community unprecedented access to data.
The inside story of England COVID pandemic described in new study
The Covid-19 crisis that gripped the UK between September 2020 and June 2021 can be thought of as a series of overlapping epidemics, rather than a single event, say researchers at the Wellcome Sanger Institute, EMBL’s European Bioinformatics Institute (EMBL-EBI) and their collaborators.
Mutations in liver cells linked to liver disease and fat metabolism
For the first time, DNA mutations in liver cells have been identified that impact metabolism and insulin sensitivity in patients with liver disease. These mutations are specific to liver disease that is associated with obesity, type 2 diabetes, and chronic alcohol consumption.
Mutated cells drive out early tumours from the oesophagus
Cells carrying mutations can out compete early tumours in the mouse oesophagus, so they never make it into cancers, new research has shown.
Higher rates of mutation alone are not to blame for age related disease
New research exploring theories of ageing has found that small mutations accumulating in DNA are unlikely to be fully responsible for this process.
Cell atlas reveals how blood and immune systems form in developing bone marrow
The first comprehensive analysis of how the blood and immune systems develop in prenatal bone marrow has been conducted by scientists at the Wellcome Sanger Institute, Newcastle University and their collaborators.
Georgians, jet engines and genes: New public event uncovers the history of Cambridgeshire’s Hinxton Hall
A new series of online talks, culminating in a virtual and physical exhibition, will celebrate the storied history of Hinxton Hall in Cambridgeshire, a historically important site that is now part of the world-renowned Wellcome Genome Campus.
International research consortium to tackle tumour drug resistance using single-cell sequencing
Sanger Institute scientists join a new collaborative research project that will use single-cell sequencing to tackle drug resistance and develop smarter therapeutic strategies for cancer.
Loss of gene linked to differences in brain size
An inactivated gene found naturally in some people leads to a difference in brain size, without having a detectable impact on health or disease, new research has found.
Sanger scientists receive Chan Zuckerberg Initiative grants to study childhood diseases
Several projects involving researchers from the Wellcome Sanger Institute have been awarded Chan Zuckerberg Initiative (CZI) Paediatric Networks for Human Cell Atlas grants to study childhood diseases using single-cell technologies.
Researchers discover individual variation in how our bodies develop and acquire mutations
New insights into how the human body develops from one cell into trillions, and the genetic mutations that cells pick up along the way, have been generated by two studies from scientists at the Wellcome Sanger Institute, the University of Cambridge and their collaborators.