The Rayner and Deane Laboratories at the Cambridge Institute for Medical Research are recruiting a Postdoctoral Research Associate to work as part of an ongoing team project that explores the function of a multi-gene family that has expanded in the genomes of Plasmodium vivax and other related neglected human malaria parasites, and have been highlighted as potential vaccine targets. The project builds on a recent publication that established that these tryptophan-rich antigens (TRAgs) have lipid binding activity (PMID: 37709739), suggesting they may be involved in remodelling membranes. It will use CRISPR/Cas9 genetic modification to knockout and tag multiple TRAg genes in P. knowlesi, as well as work with lines already generated by other team members and explore the function of these genes using a range of cell biological and biochemical assays.
This is a short-term position so it will be absolutely essential that the successful candidate has demonstrable experience in culturing and transfecting Plasmodium parasites, with experience working with P. knowlesi particularly desirable. The candidate must also have extensive experience in using molecular biology techniques (eg Gibson assembly) to generate and validate complex genetic manipulation vectors, as well as in relevant cell biology techniques such as immunofluorescence, expansion and live imaging microscopy and flow cytometry.
The primary focus will be on carrying out outstanding academic research which will contribute directly to collaborative papers. The project provides substantial scope for innovation, creativity and exercising scientific judgement. You will work as part of a vibrant interdisciplinary team with colleagues in both the Rayner and Deane labs in the Cambridge Institute for Medical Research. You are expected to contribute to that positive team environment, supporting and training others where needed and working together to create the best possible outputs within the time available.
The Cambridge Institute for Medical Research (CIMR) is located on the Cambridge Biomedical Campus and it is a collaborative institute at the interface between fundamental research and the clinic, with a mission to determine the molecular mechanisms of disease in order to advance human health.
This is a full-time fixed-term post for 1 year from the start date.
Informal enquiries to Professor Julian Rayner [email protected]
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
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Please ensure that you upload a covering letter and CV in the Upload section of the online application. The covering letter should outline how you match the criteria for the post and why you are applying for this role. If you upload any additional documents which have not been requested, we will not be able to consider these as part of your application.
Please include details of your referees, including email address and phone number, one of which must be your most recent line manager.
Closing Date: 5th August 2026
Interview Date: as soon as possible after application closing date
Please quote reference SG50311 on your application and in any correspondence about this vacancy.
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