Computational solutions for drug discovery

Our companies

Cresset is a software development and contract research organization that delivers solutions enabling companies to discover, design and optimize molecules. Cresset is also a development partner for Torx Software, a platform that enables better design decisions and tracking compound synthesis. For over 20 years we have helped organizations improve human health by providing solutions that enable them to develop better treatments for critical diseases. Our global customer-base includes pharmaceutical, biotechnology, agrochemical, flavor and fragrance companies, and academics.

Exceptional talent

Cresset has seen significant organic growth and, with investment backing, we on a rapid growth trajectory across all areas of the business to deliver not only outstanding solutions for our customers, but to recognize the outstanding talent who choose to advance their career with Cresset. Personal professional development is at the heart of our commitment to all employees – we take great pride in seeing colleagues progress their career within the company.

New product development driven by best-in-class infrastructure

New product development is crucial so that we deliver the drug discovery tools of the future. Alongside enhancing existing science and technology we have a strong greenfield project pipeline and encourage our highly experienced software developers, computational chemistry developers and talented colleagues to take ownership of these projects and drive them through the development process.

We commit to providing you with the tools to do your job to its fullest potential. We invest significantly in cutting-edge server and network infrastructure to ensure our colleagues have access to best-in-class technology to deliver the reliable solutions our customers depend on us for.

Products and services

Flare™ ligand-based and structure-based drug design

A single platform for ligand-based and structure-based drug design that enables research chemists to discover novel small molecules more efficiently and effectively.

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Contract research

Flexible scientific consulting and contract research solutions for a wide variety of organizations using our innovative field-based chemistry software, our unique XED molecular mechanics force field, as well as more traditional approaches.

Project consulting

Cresset can contribute to your projects at various stages and to the degree that suits your needs. We can run whole lead discovery and optimization projects or just help you overcome obstacles in your path. We have successfully concluded many contract research and scientific consulting projects with our customers, many of whom have come back time and time again for additional services. Because Cresset’s technology can work with or without a structure of the target protein it can be used on the widest range of target classes. To discuss how we can help with your project, please contact us.

Software as a Service (SaaS)

If your team has plenty of chemistry expertise but not the technology, we can help bridge the gap by renting Blaze software to you through a secure cloud-based portal. You’ll have access to one of the most powerful screening technologies in the world, but you’ll only pay for what you need, and because we rent Blaze to you on a per-project basis you have the flexibility to complete your project in a timeline that works for you. Contact us to learn more about Software as a Service.

CompChem on Demand

Cresset’s computational chemistry experts can be hired on a daily basis to work for you as needed. Simply purchase the number of days you need and then call us to work for you anytime within the next year. This is a flexible way to gain Cresset’s expertise and complete difficult projects while ensuring a high value result for your company.

The Cresset experts have a wide variety of skills including:

  • Scaffold hopping.
  • Library design.
  • Ligand based virtual screening.
  • Fragment replacement.
  • Fragment growth.
  • SAR analysis including 3D QSAR using fields.
  • Patent analysis.
  • Lead optimization.
  • And much more.

Contact us for more details about CompChem on Demand.

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Blaze™: Effective ligand based virtual screening

Effective ligand based virtual screening

Dramatically increase your wet screening hit rate at a fraction of the cost with a biologically intelligent search of chemical databases.

Blaze uses the shape and electrostatic character of known ligands to rapidly search large chemical collections for molecules with similar properties.  It is excellent for replacing peptides with non-peptides and steroids with non-steroids, as well as finding novel leads from screening hits or known drug structures.

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Discover new directions for your project using bioisosteres

Spark is an exciting and powerful way of generating novel and diverse structures for your project. Spark uses Cresset’s field technology to find biologically equivalent replacements for key moieties in your molecule, enabling you to find new structures in new chemical space.

Use Spark to optimize your leads and improve your IP position, or to switch scaffolds completely while retaining activity and minimizing ADME and toxicity issues.

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