Cresset
Computational solutions for drug discovery
Cresset® is leading the digital revolution in molecule design and cross-team communication. We combine cutting-edge science with AI/ML to enable our customers to advance human health by discovering new compounds faster and more efficiently. Built from 20 years of computational chemistry innovation from working directly on customer problems, we provide an unrivalled platform for discovery organizations to achieve scientific success.
Our intuitive in silico CADD software programs combine unique ligand-based and structure-based computational methods, while the Torx® DMTA cloud application facilitates secure, real-time collaboration between chemistry teams, CROs and external partners. Our Discovery CRO services provide customers with tailored molecular modeling solutions, the latest techniques and custom integration to advance their projects, while creating, broadening and protecting IP.
By harnessing digital transformation to accelerate communication across the workflow, Cresset’s trusted, pioneering solutions empower organizations to make quicker, more informed decisions and design the molecules that matter.
Products and services
Flare™ ligand-based and structure-based drug design
A single platform for ligand-based and structure-based drug design that enables research chemists to discover novel small molecules more efficiently and effectively.
Contract research
Flexible scientific consulting and contract research solutions for a wide variety of organizations using our innovative field-based chemistry software, our unique XED molecular mechanics force field, as well as more traditional approaches.
Project consulting
Cresset can contribute to your projects at various stages and to the degree that suits your needs. We can run whole lead discovery and optimization projects or just help you overcome obstacles in your path. We have successfully concluded many contract research and scientific consulting projects with our customers, many of whom have come back time and time again for additional services. Because Cresset’s technology can work with or without a structure of the target protein it can be used on the widest range of target classes. To discuss how we can help with your project, please contact us.
Software as a Service (SaaS)
If your team has plenty of chemistry expertise but not the technology, we can help bridge the gap by renting Blaze software to you through a secure cloud-based portal. You’ll have access to one of the most powerful screening technologies in the world, but you’ll only pay for what you need, and because we rent Blaze to you on a per-project basis you have the flexibility to complete your project in a timeline that works for you. Contact us to learn more about Software as a Service.
CompChem on Demand
Cresset’s computational chemistry experts can be hired on a daily basis to work for you as needed. Simply purchase the number of days you need and then call us to work for you anytime within the next year. This is a flexible way to gain Cresset’s expertise and complete difficult projects while ensuring a high value result for your company.
The Cresset experts have a wide variety of skills including:
- Scaffold hopping.
- Library design.
- Ligand based virtual screening.
- Fragment replacement.
- Fragment growth.
- SAR analysis including 3D QSAR using fields.
- Patent analysis.
- Lead optimization.
- And much more.
Contact us for more details about CompChem on Demand.
Blaze™: Effective ligand based virtual screening
Effective ligand based virtual screening
Dramatically increase your wet screening hit rate at a fraction of the cost with a biologically intelligent search of chemical databases.
Blaze uses the shape and electrostatic character of known ligands to rapidly search large chemical collections for molecules with similar properties. It is excellent for replacing peptides with non-peptides and steroids with non-steroids, as well as finding novel leads from screening hits or known drug structures.
Spark
Discover new directions for your project using bioisosteres
Spark is an exciting and powerful way of generating novel and diverse structures for your project. Spark uses Cresset’s field technology to find biologically equivalent replacements for key moieties in your molecule, enabling you to find new structures in new chemical space.
Use Spark to optimize your leads and improve your IP position, or to switch scaffolds completely while retaining activity and minimizing ADME and toxicity issues.
