The year-long investigation was undertaken by experts at Cambridge University Hospitals (CUH) NHS Foundation Trust, Bedfordshire Hospitals NHS Foundation Trust, the University of Bedfordshire, and volunteer patients across both counties. Now, a research paper just published in the open access journal Infectious Diseases Diagnosis & Treatment, concludes that treating the gut to a blend of five different friendly bacteria called lactobacillus probiotics, combined with a chicory-rich ingredient known as an inulin, could help with acute and long-term Covid symptoms.
Addenbrooke’s and Bedford hospitals oncology consultant, Professor Robert Thomas (pictured), says the study started after researchers worldwide began reporting that Covid patients were suffering a disruption in the ratio of friendly to unfriendly bacteria in the gut, called dysbiosis. This was especially true of those with gastrointestinal (GI) symptoms such as nausea, indigestion and diarrhoea.
Then, London’s Kings College developed an app-based study, involving over 400,000 people, which showed those who took regular probiotic supplements had a lower risk of catching Covid. Until now, it was not known whether taking probiotics after catching Covid could help. This research suggests they do - or more precisely a specific blend of lactobacillus probiotic and a chicory-rich inulin. (Inulin is a prebiotic which helps feed the lactobacillus in the capsule and other friendly bacteria in the gut).
The study involved 126 people, a third of whom had an acute Covid infection with the majority reporting a wide variety of longer term symptoms lasting over 100 days. Results, analysed by university statisticians showed that cough, fatigue, gut and well-being scores improved. Many said gut symptoms suffered for years were resolved.
Dr Thomas said: “Such a rapid improvement in the majority who had been experiencing symptoms for over eight months was clinically relevant and welcomed, especially among those more likely to have pre-existing gut dysbiosis. The authors believe that the importance of interventions to improve gut health should be emphasised to people with Covid.
“Going forwards, our research group is analysing the second phase of this study, which evaluated whether a whole phytochemical rich nutritional capsule, in additional to the probiotics, could further enhance Covid recovery.
“In addition, with the support of Roche pharmaceuticals, they are evaluating whether intake of this blend together with vitamin D could also enhance antibody titres levels post-Covid vaccination.”
Earlier this year Professor Thomas and colleagues in Cambridge and Bedford published the findings of a study that identified that pomegranate, turmeric, tea and broccoli could ease common symptoms of menopause.