Impact of DNA mutations on lifelong blood cell production uncovered
New research has uncovered how genetic mutations hijack the production of blood cells in different periods of life. Scientists at the Wellcome Sanger Institute, the Cambridge Stem Cell Institute, EMBL’s European Bioinformatics Institute (EMBL-EBI) and collaborators show how these changes relate to ageing and the development of age-related diseases, including blood cancer.
Cellular secrets of ageing unlocked by researchers
New research has uncovered how genetic changes that accumulate slowly in blood stem cells throughout life are likely to be responsible for the dramatic change in blood production after the age of 70.
Birmingham 2022 Queen’s Baton Relay to visit Wellcome Genome Campus as full England route revealed
Baton will visit Wellcome Genome Campus in South Cambridgeshire on 9 July 2022 ahead of the Commonwealth Games.
New bacteria associated with inflammatory bowel disease discovered in mice
New disease-causing bacteria have been identified in the guts of laboratory mice.
New research - mini guts used to study early stages of whipworm infection
For the first time, researchers have unearthed what happens in the body in the early stages of infection with the parasitic nematode, whipworm.
New analysis sheds light on how to uncover causal variants for immune-mediated diseases
New genetic analysis has reanalysed existing data to try and pinpoint the genetic variants that cause 12 different immune-mediated diseases, such as inflammatory bowel disease, multiple sclerosis, and rheumatoid arthritis.
Evolutionary pressures on genes associated with childlessness
New research suggests that genetic variants that damage the genome are associated with reduced reproductive success and an increased likelihood of not having children.
New hope for treatment of infant cancer that has puzzled researchers for decades
New research has begun to unravel the mystery of why a particular form of leukaemia in infants has defied efforts to improve outcomes, despite significant improvements in treating older children.
New drug combinations found for resistant cancers
Sanger researchers have created the world’s largest novel resource using systematic drug testing and genetics analyses to show new potential drug combinations for breast, colon, and pancreatic cancer.
Genomic study shows that England’s travel quarantine measures were effective – up to a point
More than half of imported cases during period studied came from just three countries.
New research finds motivations to take part in research vary around the world
New research has suggested that some public audiences around the world are motivated to take part in genetic research if they receive their results back but is this not the only motivating factor for many.
Wellcome Connecting Science - first of its kind global Covid-19 genomics training programme launches
A new, global training programme that aims to provide deeper understanding about SARS-CoV-2 genomics and biodata, and how this knowledge can be used to prepare for future pandemics has been launched by COG-Train.
Adult blood cancer-causing mutations occur in early childhood
Genetic mutations causing a type of adult blood cancer occur in childhood or even in the womb, new research has shown.
Unprecedented cellular maps of tissue enabled by new tool
The study of the human body at single-cell level has received a boost with the creation of a new tool, which will allow researchers to see not only the function of cells, but also where they are situated within tissues.
Rapid immune response in children protects them from COVID-19, genetic study finds
Fundamental differences in the immune response of adults and children can help to explain why children are much less likely to become seriously ill from SARS-CoV-2, according to new research from the Wellcome Sanger Institute, University College London and their collaborators.
New centre to foster global conversations about ethical issues raised by science
The University of Cambridge and Wellcome Connecting Science announce the launch of the Kavli Centre for Ethics, Science, and the Public, to engage publics and scientists with the ethical implications of scientific discovery and its impact on society.
Sanger Institute launches Fellowship programme to support next generation of Black scientists
The Wellcome Sanger Institute has today (8 December) launched the Sanger Excellence Postdoctoral Fellowship − a Fellowship designed to support the training and career development of scientists from Black backgrounds.
Human parasite’s daily rhythms could be targeted for better treatments
For the first time, the worm that causes schistosomiasis has been shown to have a daily rhythm that impacts which genes are switched on at different times.
Uterus study is important step towards understanding diseases that affect one third of women
The most comprehensive cell atlas to date of the human uterus has identified two new epithelial cell states that can be used to distinguish two forms of uterine cancer. Researchers from the Wellcome Sanger Institute, the University of Cambridge and their collaborators also identified the genetic pathways that determine two main endometrial cell types.
Sanger celebrates Highly Cited Researchers
A number of researchers from the Wellcome Sanger Institute have been named on Clarivate's Highly Cited list.
Researchers will map immune cells across Latin America with support from CZI
A new grant awarded to the Wellcome Sanger Institute and international collaborators within seven Latin American countries by the Chan Zuckerberg Initiative (CZI) will fund the first high-resolution genetic atlas of immune cells in Latin America, uncovering new information about health and disease.
Sanger researchers to tackle deadly brain cancer with ‘tissue time machine’
Sanger Institute scientists are starting a new project that will integrate information from spatial transcriptomics with single-cell RNA and DNA sequencing, to understand how brain cancer develops.
New database of 660,000 assembled bacterial genomes sheds light on the evolution of bacteria
A vast, curated collection of bacterial genomes has been created that allows the community unprecedented access to data.
The inside story of England COVID pandemic described in new study
The Covid-19 crisis that gripped the UK between September 2020 and June 2021 can be thought of as a series of overlapping epidemics, rather than a single event, say researchers at the Wellcome Sanger Institute, EMBL’s European Bioinformatics Institute (EMBL-EBI) and their collaborators.
Mutations in liver cells linked to liver disease and fat metabolism
For the first time, DNA mutations in liver cells have been identified that impact metabolism and insulin sensitivity in patients with liver disease. These mutations are specific to liver disease that is associated with obesity, type 2 diabetes, and chronic alcohol consumption.