Until recently, the majority of studies that explore the mechanisms underlying the microbiome-gut-brain axis relied almost exclusively on animal models. Despite the great progress made with these models, various limitations, including ethical considerations and interspecies differences that limit the translatability of data to human systems, pushed researchers to seek for alternatives. Physiologically relevant in vitro human models, as well as advanced tools to study in vivo animal models, are urgently required.
Professor Owens will start by introducing her group’s progress in generating a complete platform of the human microbiota-gut-brain axis with integrated monitoring and sensing capabilities. This platform has been designed by bringing together principles of materials science, tissue engineering, 3D cell biology and bioelectronics, and has allowed the group to build advanced models of the gastrointestinal tract and brain, with integrated real-time and label-free electronic monitoring, aiming to elucidate the role of microbiota in the gut-brain axis communication. She will then talk about conformable electronic devices developed for both ex-situ measurements of GI tissue from rats, as well as in vivo experiments in liverats. These devices allow highly sensitive monitoring of impedance of the tissue (as an indicator of gut health) as well as the enteric nervous system.
Biography: Róisín M. Owens is Professor of Bioelectronics at the Dept. of Chemical Engineering and Biotechnology in the University of Cambridge and a Fellow of Newnham College. She received her BA in Natural Sciences (Mod. Biochemistry) at Trinity College Dublin, and her PhD in Biochemistry and Molecular Biology at Southampton University. She carried out two postdoc fellowships at Cornell University, on host-pathogen interactions of Mycobacterium tuberculosis in the dept. of Microbiology and Immunology with Prof. David Russell, and on rhinovirus therapeutics in the dept. of Biomedical Engineering with Prof. Moonsoo Jin. From 2009-2017 she was a group leader in the dept. of bioelectronics at Ecole des Mines de St. Etienne, on the microelectronics campus in Provence. Her current research centers on application of organic electronic materials for monitoring biological systems in vitro, with a specific interest in enhancing the biological complexity and adapting the electronics to be fit for purpose. She has received several awards including the European Research Council starting (2011), proof of concept grant (2014) and consolidator (2016) grants, a Marie Curie fellowship, and an EMBO fellowship. She currently serves as co-I and co-director for the EPSRC CDT in Sensor Technologies, renewed in 2019. She is a 2019 laureate of the Suffrage Science award. From 2014-2020, she was principle editor for biomaterials for MRS communications (Cambridge University Press), and she serves on the advisory board of Advanced BioSystems and Journal of Applied Polymer Science (Wiley). In 2020 she became Scientific Editor for Materials Horizons (RSC). She is author of 100+ publications and 2 patents and her work has been cited more than 6000 times.
This event is free to anyone to attend. Please register online below so we have an idea of numbers.
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Key Contacts: If you have any questions please contact engagement-coordinator@maxwell.cam.ac.uk or Louise.Rushworth@cambridgenetwork.co.uk
Please follow @CambNetwork and @Maxwell_Centre and tweet about this event using #CNMaxwell #cnevents. Prof Owens twitter feed is @biochemist_hero.
This is part of a series of more-or-less termly talks ‘From discovery science to industrial application’ run jointly over the last 5 years by Cambridge Network and the University of Cambridge’s Maxwell Centre. We feature scientists whose research will possibly be commercialised in the next few years.
