Brain cells created from patients’ skin cells

Cambridge scientists have, for the first time, created cerebral cortex cells – those that make up the brain’s grey matter – from a small sample of human skin. The researchers’ findings, which were funded by Alzheimer’s Research UK and the Wellcome Trust, have been published in 'Nature Neuroscience'.

Diseases of the cerebral cortex range from developmental conditions, such as epilepsy and autism, to neurodegenerative conditions such as Alzheimer’s.  Today’s findings will enable scientists to study how the human cerebral cortex develops, how it ‘wires up’ and how that can go wrong (a common problem leading to learning disabilities).
 
It will also allow them to recreate brain diseases, such as Alzheimer’s, in the lab.  This will give them previously impossible insight, allowing them to both watch the diseases develop in real time and also develop and test new drugs to stop the diseases progressing.

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Image: Neural stem cells  Credit: Yichen Shi (Livesey Lab) University of Cambridge

Reproduced courtesy of the University of Cambridge




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