On track to reach an ambitious goal of 3,000 genomes sequenced by the end of 2022.
Biomedical research depends on shared access to human data and streamlining consent to use these data will facilitate discovery. The GA4GH Data Use Ontology (DUO) provides standard terms and definitions for use of biomedical data obtained through informed consent. Standardising this vocabulary allows for automated access to sensitive biomedical data.
Researchers have assembled and characterised more than 660,000 bacterial genomes from publicly-available DNA data. Public databases are huge mixed collections of raw data and genomes of widely varying quality, but the new dataset, which is open to the research community, makes it easier to search bacterial genomes for features of interest and examine their evolutionary relationships.
An independent study by management consultancy Charles Beagrie Ltd has found that the data resources managed by EMBL’s European Bioinformatics Institute (EMBL-EBI) offer exceptional value for money. The report estimated that the return on investment in research and development depending on EMBL-EBI managed data is worth £1.3 billion annually.
A new platform called 3D-Beacons Network brings together experimentally determined and predicted protein structure models and related data from several providers and makes them freely available, all in one place.
A collaboration between EMBL-EBI’s European Nucleotide Archive (ENA) and the Global Biodiversity Information Facility (GBIF) has established automated processes for publishing better organised, cleaner and more up-to-date datasets on GBIF.
Researchers have combined spatial gene expression information with single-cell genomics data to create a high-resolution atlas of mouse organogenesis.
DeepMind is partnering with the European Molecular Biology Laboratory (EMBL) to make the most complete and accurate database yet of the predicted human protein structures freely and openly available to the scientific community
Bioimaging has advanced in leaps and bounds in recent years, giving researchers a closer view of how life works at a cellular, molecular and even atomic level.
Researchers use large-scale human genetic studies to identify drug targets important for managing COVID-19 in its early stages.
Scientists and healthcare providers are beginning to use a new approach for assessing a person's inherited risk for complex diseases such as Type 2 diabetes, coronary heart disease and breast cancer, which involves calculating a polygenic risk score (PGS). The score provides an estimate of an individual’s risk for the disease, based on their DNA changes related to those diseases.
EMBL’s European Bioinformatics Institute (EMBL-EBI) has launched the Genome Integrations with Function and Sequence (GIFTS). GIFTS enables users of Ensembl or UniProt searching for a specific gene or protein to view the corresponding protein or genomic data. GIFTS is available as a new independent platform regularly updated by both services.
The river Cam, which flows through the city of Cambridge, UK, is a hotspot for swimmers, rowers, and kayakers, many of whom develop waterborne infections caused by the bacteria found in the river.
All living things are made of proteins, and each of the millions of proteins out there has its own unique shape. Although we don’t know what the majority of proteins look like, over 170,000 3D structures are stored in the Protein Data Bank in Europe (PDBe), a database hosted at EMBL’s European Bioinformatics Institute (EMBL-EBI).
EMBL-EBI’s Group Leader, John Marioni, has been selected as a finalist in the 2021 Blavatnik Awards for Young Scientists in the UK. Marioni has recently been appointed as EMBL-EBI’s new Head of Research, set to start his new role in March 2021.
In March 2020, the World Health Organization declared COVID-19 a pandemic. Since then, COVID-19 has become overwhelmingly present in our lives, and researchers are working tirelessly to understand the virus. Within the field of bioinformatics, many have been expanding, adapting, and developing data analysis tools to study coronaviruses.
The world’s oceans are facing a worrying suite of threats caused by humans. Marine ecosystems are changing faster than ever before, as a result of overfishing, pollution, and global warming – which causes changes in ocean chemistry and threatens marine species. These silent shifts will have profound impacts on animals and people everywhere, so understanding them is crucial.
Even before Emmanuelle Charpentier and Jennifer Doudna won the 2020 Nobel Prize in Chemistry for the development of CRISPR-Cas9, genome editing had become a household name. With the technology increasingly being used in life science research, the need to collate and organise these datasets is becoming increasingly clear.
Love it or hate it, artificial intelligence* (AI) is becoming embedded into all aspects of life. From self-driving cars to analysing legal cases, deciding which social media posts you see or making healthcare more personalised, the applications of AI are endless.
EMBL signs MoU to fortify collaborative status with Centre d’Immunologie de Marseille-Luminy.
Drug targets common across three coronavirus strains could be used for rapid treatment response against emerging coronavirus strains.
The Global Alliance for Genomics and Health (GA4GH) has co-released a series of software demos that showcase real-world interoperability across the international genomics community.
The European Molecular Biology Laboratory (EMBL) is part of a growing movement to achieve cell-based medicine in Europe. This week hundreds of leading scientists, clinicians, industry leaders, and policymakers from around Europe declared this a new age for cell-based medicine by publishing a perspective piece, ‘Towards cell-based medicine in Europe’.
Researchers have sequenced the genome of the tuatara, revealing its unique evolutionary history.
COVID-19 research papers and preprints are currently published across many repositories, in formats that make large-scale analyses difficult. To help researchers search and access preprints more effectively, Europe PMC, the literature archive of EMBL’s European Bioinformatics Institute (EMBL-EBI), has begun indexing full-text COVID-19 preprints along with the associated data.